From having a little info on conference realignment last time around I can tell you that the sec is probably most likely if they were to expand. This would depend on how the cards fall.
Pros: consistency in athletics and commitment from the school.
Ratings are middle of the road, but consistent enough.
Con: the major one that made wvu not a consideration from the big and acc last time was academics.
The market they bring isn't a huge one, and it's not a growing market. (Not as important as it once was)
It's tough to tell what will happen. I don't think the acc or big are going to invite wvu unless there are some other moves that are happening or rumored to happen. Both conferences still hold pretty tight to academics, and I'm going to call a spade a spade, but wvu doesn't have the academic reputation to satisfy everyone in those two conferences.
I can see wvu moving into the sec as they continue to try to expand. I would be surprised if it happens without another school moving first, but it could.
It seems strange that so many other factors come into play, and that athletics are less important. (It unfairly discriminates against wvu a little)
However, if a move is made it will be interesting to see what happens. The big 12 is certainly looking volatile.