It's a clash of an elite offensive team vs an elite defensive team. Although WVU is averaging just 2 less points a game than OU, but still that's the overall match-up I see.
The press should be problematic for OU, which is somewhat susceptible to turning it over and lacks a deep bench.
The key to me is taking care of the ball & WV's half-court offense. If they can again attack the paint, draw fouls on OU and score a bunch at the free throw line, they'll have a shot. That would allow WV to set the press after a made free throw and would test OU's starters getting heavy minutes and/or bench having to show up. The free throw disparity won the Kansas game.
Watching Ok State's freshman guard score 42 on the Sooners, it would appear they are vulnerable to guards driving in the lane, scoring or at least getting fouled. Not to mention Ok State doesn't have a front court player like Williams who can also draw fouls & hit FTs.